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Jianan Qu
Ph.D, Chinese Academy of Sciences
Fellow, OSA
Fellow, SPIE


 


Professor Tel: (852) 2358-8541 Fax: (852) 2358-1485  E-mail: eequ@ust.hk  Office: Room 2434


 

ACADEMIC EXPERIENCES AND QUALIFICATIONS:

1997 - present:  Assistant/Associate/Full Professor, Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology 
2007 - 2010:     Director of Postgraduate Programme, Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology 
Summer/2006:  Invited Professor, Swiss Federal Institute of Technology (Ecole Polytechnique Federale de Lausanne), Switzerland  
Summer/2005:  Visiting Associate Professor, Beckmann Laser Institute and Department of Surgery, University of California, Irvine, USA 
1995 - 1997:     Staff Scientist, Division of Biophysics and Bioimaging, Ontario Cancer Institute, Toronto, Canada.  
1991 - 1994:     Postdoctoral Research Associate, Department of Physics, University of California, Irvine, USA; British Columbia Cancer Research Center, Vancouver, Canada.  
1986 - 1990:     Ph.D in Optics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, China
 

RESEARECH INTERESTS:

Biophotonics; modern optical devices and systems; optical imaging processing; laser spectroscopy; environmental monitoring.
 

PROFESSIONAL ACTIVITIES:

Editorship:
Topical editor,  Optics Letters
Editorial board,  Journal of Biomedical Optics
Editorial board,  International Journal of Optics,
Editorial board,  Chinese Journal of Lasers

Professional affiliation:
Elected Fellow,   The Optical Society of America (OSA)
Elected Fellow,   The International Society for Optics and Photonics (SPIE)

Conference organization (major international conferences):
Member of program committee,   Topical Meeting on Biomedical Optics, Optical Society of America, April 29- May 2, 2012, Miami, Florida, USA (2012)
Theme chair,   11th OWLS Optics Within Life Sciences: Optics-based Therapeutics, Diagnostics and Analytics, September 28-30, 2010, Quebec City, Canada (2010)
Member of program committee,   Advanced Medical Imaging Technologies, Conference on Advanced Biomedical and Clinical Diagnostic Systems, Society of Photo-Optical Instrumentation Engineers, San Jose, USA (2009-2017)
Member of international advisory committee,   Optics Within Life Sciences-10, July 2-4, 2008, Singapore (2008)
Member of international program committee,  International Conference on Biomedical Engineering (BioMed), Innsbruck, Austria (2004-2006, 2012)
Member of program committee,   Medical and Biological Applications, The Annual Conference on Lasers and Electro-Optics (CLEO), IEEE/LEOS (Lasers and Electro-Optics Society) and Optical Society of America, USA (2003-2004, 2011-2012)
Member of executive committee,  European Conference on Biomedical Optics, Munich, Germany (2003)
Member of program committee,   Conference of Diagnostic Optical Spectroscopy in Biomedicine, Optical Society of America and Society of Photo-Optical Instrumentation Engineers, Munich, Germany (2001, 2003)

Referee for scientific journals:
ACS Nano, Advanced Functional Materials, Analytical Chemistry, Applied Optics, Applied Spectroscopy, Biomedical Optics Express, IEEE Journal of Selected Topics in Quantum Electronics, Journal of Biomedical Optics, Journal of Cancer Detection and Prevention, Journal of Optical Society of America-B, Journal of Raman Spectroscopy, Journal of Visualized Experiments (JoVE), Lasers in Surgery and Medicine, Nature Commuincations, Optics Letters, Optics Express, Photochemistry and Photobiology, PLOS ONE, Scientific Reports, Theranostics
 

Selected Publications (peer-reviewed journals)

Zhongya Qin, Zhentao She, Congping Chen, Wanjie Wu, Jackie K.Y. Lau, Nancy Y. Ip and Jianan Y. Qu, “Deep tissue multi-photon imaging using adaptive optics with direct focus sensing and shaping" , Nature Biotechnology , (Accepted). doi: https://doi.org/10.1101/2021.08.04.455159
Wanjie Wu, Sicong He, Junqiang Wu, Congping Chen, Xuesong Li, Kai Liu and Jianan Y. Qu, “ Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window”, Nature Communications , V. 13, 1959 (2022). https://doi.org/10.1038/s41467-022-29496-x PDF; Supplementary Information
Wanjie Wu, Xuesong Li., Janan Qu, and Sicong He, "in vivo Imaging of Biological Tissues with Combined Two-Photon Fluorescence and Stimulated Raman Scattering Microscopy", J. Vis. Exp. (JoVE) (178), e63411, https://dx.doi.org/10.3791/63411 (2021)
Congping Chen, Zhentao She, Peng Tang, Zhongya Qin, Jufang He and JiananY.Qu, "Study of neurovascular coupling by using mesoscopic and microscopic imaging", iScience, V. 24, 10, 22 October 2021, 103176 https://doi.org/10.1016/j.isci.2021.103176 PDF
Lidan Zeng, Xuesong Li, Christopher B. Preusch, Gary J. He, Ningyi Xu, Tom H. Cheung, Jianan Qu and Ho Yi Mak, "Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans", PLoS Genetics, 17(7): e1009635. (2021) https://doi.org/10.1371/journal.pgen.1009635 PDF
Congping Chen, Zhongya Qin, Sicong He, Shaojun Liu, Shun-Fat Lau, Wanjie Wu, Dan Zhu, Nancy Y. Ip and Jianan Y. Qu, "High-resolution two-photon transcranial imaging of brain using direct wavefront sensing", Photonics Research, Vol. 9, Issue 6, pp. 1144-1156 (2021) https://doi.org/10.1364/PRJ.420220 PDF
Ye Wang, Wing-Yu Fu, Kit Cheung, Kwok-Wang Hung, Congping Chen, Hongyan Geng, Wing-Ho Yung, Jianan Y. Qu, Amy K. Y. Fu and Nancy Y. Ip, "Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus", Proceedings of the National Academy of Sciences of the United States of America, V.118, (2021), https://doi.org/10.1073/pnas.2020810118 PDF
Zhongya Qin, Congping Chen, Sicong He, Ye Wang, Kam Fai Tam, Nancy Y. Ip and Jianan Y. Qu, "Adaptive optics two-photon endomicroscopy enables deep brain imaging at synaptic resolution over large volumes", Science Advances, 30 Sep 2020: Vol. 6, no. 40, eabc6521 DOI: 10.1126/sciadv.abc6521 PDF Supplementary Materials
Qixin Wei, Sicong He, Jianan Qu and Jiang Xia, "Synthetic Multienzyme Complexes Assembled on Virus-like Particles for Cascade Biosynthesis In Cellulo", Bioconjugate Chemistry, 2020, 31, 10, 2413–2420, PDF
Miao Liu, Sicong He, Lixin Cheng, Jianan Qu and Jiang Xia, "Phase-Separated Multienzyme Biosynthesis", Biomacromolecules, V.21, P.2391-2399 (2020) PDF
Sicong He, Jin Xu, Jianan Qu and Zilong Wen, "Lightening the Way of Hematopoiesis: Infrared Laser-Mediated Lineage Tracing With High Spatial-Temporal Resolution", Experimental Hematology, V.85, P.3-7 (2020) PDF
Zhongya Qin , Sicong He , Chao Yang, Jasmine Sum-Yee Yung, Congping Chen, Christopher Kai-Shun Leung, Kai Liu and Jianan Y. Qu, "Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo", Nature: Light Science & Applications, (2020)9:79, https://doi.org/10.1038/s41377-020-0317-9 PDF
Shun-Fat Lau, Congping Chen, Wing-Yu Fu, Jianan Y. Qu, Tom H. Cheung, Amy K.Y. Fu, Nancy Y. Ip, "IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer's Disease", Cell Reports, V.31, 107530 (2020) PDF
Sicong He, Ye Tian, Shachuan Feng, Yi Wu, Xinwei Shen, Kani Chen, Yingzhu He, Qiqi Sun, Xuesong Li, Jin Xu, Zilong Wen, Jianan Y Qu, " In vivo single-cell lineage tracing in zebrafish using high-resolution infrared laser-mediated gene induction microscopy", eLife 2020;9:e52024, DOI: 10.7554/eLife.52024, PDF
Sicong He, Xiuqing Wei, Zhongya Qin, Congping Chen, Zhenguo Wu and Jianan Y. Qu, "In vivo study of metabolic dynamics and heterogeneity in brown and beige fat by label-free multiphoton redox and fluorescence lifetime microscopy", Journal of Biophotonics, 2019;e201960057. https://doi.org/10.1002/jbio.201960057 PDF
Wei Kang, Tian Ma, Min Liu, Jiale Qu, Zhenjun Liu, Huawei Zhang, Bin Shi, Shuai Fu, Juncai Ma, Louis Tung Faat Lai, Sicong He, Jianan Qu, Shannon Wing-Ngor Au, Byung Ho Kang, Wilson Chun Yu Lau, Zixin Deng, Jiang Xia & Tiangang Liu, "Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux", Nature Communications, (2019) 10:4248 PDF
Zhe Cao, Yan Hao, Chun Wing Fung, Yiu Yiu Lee, Pengfei Wang, Xuesong Li, Kang Xie, Wen Jiun Lam, Yifei Qiu, Ben Zhong Tang, Guanghou Shui, Pingsheng Liu, Jianan Qu, Byung-Ho Kang and Ho Yi Mak, "Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain", Nature Communications, (2019) 10:2902 PDF
Xuesong Li, Yan Li, Meijuan Jiang, Wanjie Wu, Sicong He, Congping Chen, Zhongya Qin, Ben Zhong Tang, Ho Yi Mak, and Jianan Y. Qu, "Quantitative Imaging of Lipid Synthesis and Lipolysis Dynamics in Caenorhabditis elegans by Stimulated Raman Scattering Microscopy", Analytical Chemistry, Vol.91 (3), 2279-2287 (2019) Article, SI
Congping Chen, Zhuoyi Liang, Biao Zhou, Xuesong Li, Caleb Lui, Nancy Y. Ip and Jianan Y. Qu, "In Vivo Near-infrared two-photon imaging of amyloid plaques in deep brain of Alzheimer's disease mouse model", ACS Chemical Neuroscience, Vol. 9, No.12, 3128-3136 (2018) PDF
Zhongya Qin, Qiqi Sun, Yue Lin, Sicong He, Xuesong Li, Congping Chen, Wanjie Wu, Yi Luo and Jianan Y. Qu, "New fluorescent compounds produced by femtosecond laser surgery in biological tissues: the mechanisms", Biomedical Optics Express, Vol. 9, No. 7, 3374-90 (2018) PDF
Sicong He, Jiahao Chen, Yunyun Jiang, Yi Wu, Lu Zhu, Wan Jin,Changlong Zhao, Tao Yu, Tienan Wang, Shuting Wu, Xi Lin, Jianan Y Qu, Zilong Wen, Wenqing Zhang, Jin Xu, "Adult zebrafish Langerhans cells arise from hematopoietic stem/progenitor cells", eLife, Vol. 7, 15 June 2018, article number e36131, DOI: https://doi.org/10.7554/eLife.36131.001 (2018) PDF
Guangle Niu, Ruoyao Zhang, John P. C. Kwong, Jacky W. Y. Lam, Congping Chen, Jianguo Wang, Yuncong Chen, Xing Feng, Ryan T. K. Kwok, Herman H.-Y. Sung, Ian D. Williams, Mark R. J. Elsegood, Jianan Qu, Chao Ma, Kam Sing Wong, Xiaoqiang Yu and Ben Zhong Tang, "Specific Two-Photon Imaging of Live Cellular and Deep-Tissue Lipid Droplets by Lipophilic AIEgens at Ultralow Concentration", Chemistry of Materials, Vol. 30 (14), 4778-4787 (2018) PDF
Sicong He, Yitai An, Xuesong Li, Xiuqing Wei, Qiqi Sun, Zhenguo Wu and Jianan Y. Qu, "In vivo metabolic imaging and monitoring of brown and beige fat", Journal of Biophotonics, DOI: 10.1002/jbio.201800019 (2018) PDF
Qiqi Sun, Zhongya Qin, Wanjie Wu, Yue Lin, Congping Chen, Sicong He, Xuesong Li, Zhenguo Wu, Yi Luo and Jianan Y. Qu, "In vivo imaging-guided microsurgery based on femtosecond laser produced new fluorescent compounds in biological tissues", Biomedical Optics Express, Vol. 9, No. 2, 581-90 (2018) PDF
Meijuan Jiang, Ryan T. K. Kwok, Xuesong Li, Chen Gui, Jacky W. Y. Lam, Jianan Qu and Ben Zhong Tang, "A simple mitochondrial targeting AIEgen for image-guided two-photon excited photodynamic therapy", Journal of Materials Chemistry B, Vol. 6, No.17, 2557-2565 (2018) PDF
Xuesong Li, Meijuan Jiang, Jacky W. Y. Lam, Ben Zhong Tang and Jianan Y. Qu, "Mitochondrial Imaging with Combined Fluorescence and Stimulated Raman Scattering Microscopy Using a Probe of the Aggregation-Induced Emission Characteristic", Journal of the American Chemical Society, Vol. 139, No.47, 17022-17030 (2017) PDF, SI
Ye Tian, Jin Xu, Shachuan Feng, Sicong He, Shizheng Zhao, Lu Zhu, Wan Jin, Yimei Dai, Lingfei Luo, Jianan Y. Qu, and Zilong Wen, "The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells", Journal of Experimental Medicine, Vol. 214, No.11, 3347-3360 (2017) PDF
Alexander Nicol, Ryan T. K. Kwok, Congping Chen, Weijun Zhao, Ming Chen, Jianan Qu and Ben Zhong Tang, "Ultrafast Delivery of Aggregation-Induced Emission Nanoparticles and Pure Organic Phosphorescent Nanocrystals by Saponin Encapsulation", Journal of the American Chemical Society, V.139, 14792-14799 (2017)PDF
Sicong He, Wenqian Xue, Zhigang Duan, Qiqi Sun, Xuesong Li, Huiyan Gan, Jiandong Huang and Jianan Y. Qu, "Multimodal nonlinear optical microscopy reveals critical role of kinesin-1 in cartilage development", Biomedical Optics Express, Vol. 8, 1771-1782 (2017)PDF
Wai-Leung Suen, Jun Jiang, Hoi-Sang Wong, Jianan Qu and Ying Chau, "Examination of Effects of Low-Frequency Ultrasound on Scleral Permeability and Collagen Network", Ultrasound in Medicine and Biology, V.42, 2650-2661 (2016)PDF
Tingzhong Li, Sicong He, Jianan Qu, Hao Wu, Shuizhu Wu, Zujin Zhao, Anjun Qin, Rongrong Hu and Ben Zhong Tang, "Thermoresponsive AIE polymers with fine-tuned response temperature", Journal of Materials Chemistry C, V.4 (14), 2964-2970 (2016) PDF
Xuesong Li, Wen Jiun Lam, Zhe Cao, Yan Hao, Qiqi Sun, Sicong He, Ho Yi Mak* and Jianan Y. Qu*, "Integrated femtosecond stimulated Raman scattering and two-photon fluorescence imaging of subcellular lipid and vesicular structures", Journal of Biomedical Optics, V. 20, 110501 (2015)PDF
Qiqi Sun, Wei Zheng, Jiannong Wang, Yi Luo and Jianan Y. Qu*, "Mechanism of two-photon excited hemoglobin fluorescence emission", Journal of Biomedical Optics, V. 20, 105014 (2015)PDF
Jin Xu, Lu Zhu, Sicong He, Yi Wu, Wan Jin, Tao Yu, Jianan Y. Qu* and Zilong Wen*, "Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish", Developmental Cell, V. 34, 632-641 (2015)PDF
Liguo Jiang, Yan Zeng, Qiqi Sun, Yueru Sun, Zhihong Guo, Jianan Y. Qu* and Shuhuai Yao*, "Microsecond Protein Folding Events Revealed by Time-Resolved Fluorescence Resonance Energy Transfer in a Microfluidic Mixer", Analytical Chemistry, V. 87, 5589-95 (2015)PDF
Sijie Chen, Yuning Hong, Yan Zeng, Qiqi Sun, Yang Liu, Engui Zhao, Gongxun Bai, Jianan Qu, Jianhua Hao and Ben Zhong Tang, "Mapping Live Cell Viscosity with an Aggregation-Induced Emission Fluorogen by Means of Two-Photon Fluorescence Lifetime Imaging", Chem. Eur. J., V.21, 4315-4320 (2015)PDF
Sicong He, Cong Ye, Qiqi Sun, Christopher K.S. Leung* and Jianan Y. Qu*, "In vivo Label-free nonlinear optical imaging of mouse retina", Biomedical Optics Express, V.6, No.1 (2015) PDF
Yan Zeng, Bo Yan, Jin Xu, Qiqi Sun, Sicong He, Jun Jiang, Zilong Wen* and Jianan Y. Qu*, "In vivo Nonlinear Optical Imaging of Immune Responses: Tissue Injury and Infection", Biophysical Journal, V.107, Issue of Nov. 18 (2014) PDF
Yan Zeng, Bo Yan, Qiqi Sun, Sicong He, Jun Jiang, Zilong Wen* and Jianan Y. Qu*, "In vivo micro-vascular imaging and flow cytometry in zebrafish using two-photon excited endogenous fluorescence", Biomedical Optics Express, V.5, 653-663 (2014) PDF
Qiqi Sun, Yanfeng Li, Sicong He, Chenghao Situ, Zhenguo Wu* and Jianan Y. Qu*, "Label-free multimodal nonlinear optical microscopy reveals fundamental insights of skeletal muscle development", Biomedical Optics Express, V.5, 158-166 (2014) PDF
Yan Zeng, Bo Yan, Qiqi Sun, Seng Khoon Teh, Wei Zhang, Zilong Wen* and Jianan Y. Qu*, "Label-free in vivo imaging of human leukocytes using two-photon excited endogenous fluorescence", Journal of Biomedical Optics, V.18, 040103 (2013) PDF
Seng Khoon Teh, Wei Zheng, Shuxia Li, Dong Li, Yan Zeng, Yanqi Yang* and Jianan Y. Qu*, "Multimodal nonlinear optical microscopy improves the accuracy of early diagnosis of squamous intraepithelial neoplasia", Journal of Biomedical Optics, V.18, 036001 (2013) PDF
Yan Zeng, Yun Wu, Dong Li, Wei Zheng, Wen-Xiong Wang and Jianan Y. Qu*, "Two-photon excitation chlorophyll fluorescence lifetime imaging: a rapid and noninvasive method for in vivo assessment of cadmium toxicity in a marine diatom Thalassiosira weissflogii", Planta, Published online: 18 July, 2012 PDF
Yan Zeng, Jin Xu, Dong Li, Li Li, Zilong Wen* and Jianan Y. Qu*, "Label-free in vivo flow cytometry in zebrafish using two-photon autofluorescence imaging", Optics Letters, V.37, 2490-2492 (2012) PDF
Liguo Jiang, Yan Zeng, Hongbo Zhou, Jianan Y. Qu* and Shuhuai Yao*, "Visualizing millisecond chaotic mixing dynamics in microdroplets: A direct comparison of experiment and simulation", Biomicrofluidics, V.6, 012810 (2012) PDF
Yun Wu, Yan Zeng, Jianan Y. Qu, Wen-Xiong Wang, "Mercury effects on Thalassiosira weissflogii: Applications of two-photon excitation chlorophyll fluorescence lifetime imaging and flow cytometry", Aquatic Toxicology, V. 110-111, 133-140 (2012) PDF
Wei Zheng, Dong Li, Shuxia Li, Yan Zeng, Yanqi Yang* and Jianan Y. Qu*, "Diagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer", Optics Letters, V.36, 3620-3623 (2011) PDF
Dong Li, Wei Zheng, Wei Zhang, Seng Khoon Teh, Yan Zeng, Yi Luo and Jianan Y. Qu*, "Time-resolve detection enables standard two-photon fluorescence microscope for in vivo label-free imaging of microvasculature in tissue", Optics Letters, V.36, 2638-2640 (2011) PDF
Yan Zeng, Liguo Jiang, Wei Zheng, Dong Li, Shuhuai Yao* and Jianan Y. Qu*, "Quantitative imaging of mixing dynamics in microfluidic droplets using two-photon fluorescence lifetime imaging", Optics Letters, V.36, 2236 (2011) PDF
Dong Li, Wei Zheng, Yan Zeng, Yi Luo and Jianan Y. Qu*, "Two-photon excited hemoglobin fluorescence provides contrast mechanism for label-free imaging of microvasculature in vivo ", Optics Letters, V.36, 834-836 (2011) PDF  Fig. 2 (movie 1)  Fig. 3 (movie 2)  Fig. 3 (movie 3) 
Wei Zheng, Dong Li, Yan Zeng, Yi Luo and Jianan Y. Qu*, "Two-photon excited hemoglobin fluorescence", Biomedical Optics Express, V.2, 71-79 (2011) PDF
Dong Li, Wei Zheng, Yan Zeng and Jianan Y. Qu*, "In vivo and simultaneous multimodal imaging: integrated multiplex CARS and two-photon microscopy", Applied Physics Letters, V.97, 223702 (2010) PDF
Zhe Wang, Tao Wu, Lin Shi, Lin Zhang, Wei Zheng, Jianan Y. Qu, Ruifang Niu and Robert Z. Qi, "Conserved Motif of CDK5RAP2 Mediates Its Localization to Centrosomes and the Golgi Complex", Journal of Biological Chemistry, V. 285, 22658 (2010) PDF
Wei Zheng, Dong Li and Jianan Y. Qu*, "Monitoring changes of cellular metabolism and micro-viscosity in vitro based on time-resolved endogenous fluorescence and its anisotropy decay dynamics", Journal of Biomedical Optics, V.15, 037013 (2010) PDF
Tao Wu, Tak-Hong Cheung, So-Fan Yim and Jianan Y. Qu*, "Clinical study of quantitative diagnosis of early cervical cancer based on the classification of acetowhitening kinetics", Journal of Biomedical Optics, V.15, 026001 (2010) PDF
Dong Li, Wei Zheng and Jianan Y. Qu*, "Imaging of epithelial tissue in vivo based on excitation of multiple endogenous nonlinear optical signals", Optics Letters, V.34, 2853-2855 (2009) PDF
Dong Li, Mildred S. Yang, Tao Lin, Wei Zheng and Jianan Y. Qu*, "Study of cadmium induced cytotoxicity using two-photon excitation endogenous fluorescence microscopy", Journal of Biomedical Optics, V.14, 054028 (2009) PDF
Dong Li, Wei Zheng and Jianan Y. Qu*, "Two-photon autofluorescence microscopy of multicolor excitation", Optics Letters, V.34, 202-204 (2009) PDF
Dong Li, Wei Zheng and Jianan Y. Qu*, "Time-resolved spectroscopic imaging reveals the fundamentals of cellular NADH fluorescence", Optics Letters, V.33, 2365-2367 (2008) PDF
Wei Zheng, Yicong Wu, Dong Li and Jianan Y. Qu*, "Epithelial autofluorescence: single- versus two-photon excitation", Journal of Biomedical Optics, V.13, 054010 (2008) PDF
Tao T. Wu, Tak-Hong Cheung, So-Fan Yim and Jianan Y. Qu*, "Optical imaging of cervical precancerous lesions based on active stereo vision and motion tracking", Optics Express, V.16, 11224-11230 (2008) PDF   Fig. 3 (movie)  Fig. 4 (movie)  Fig. 5 (movie) 
M.S. Yang, D. Li, T. Lin, J.J. Zheng, W. Zheng and Jianan Y. Qu*, "Increase in intracellular free/bound NAD[P]H as a cause of Cd-induced oxidative stress in the HepG2 cells ", Toxicology, V.247, 6-10 (2008) PDF
Min Xu, Tao T. Wu and Jianan Y. Qu*, "Unified Mie and fractal scattering by cells and experimental study on application in optical characterization of cellular and subcellular structures ", Journal of Biomedical Optics, V.13, 024015 (2008) PDF
Tao T. Wu and Jianan Y. Qu*, "Optical imaging for medical diagnosis based on active stereo vision and motion tracking", Optics Express, V.15, No.16, 10421-10426 (2007) PDF  MOVIE (low resolution)  MOVIE (high resolution)
Tao T. Wu, Jianan Y. Qu* and Min Xu*, "Unified Mie and fractal scattering by biological cells and subcellular structures", Optics Letters, Vol. 32, 2324-2326 (2007) PDF
Tao T. Wu and Jianan Y. Qu*, "Assessment of the relative contribution of cellular components to the acetowhitening effect in cell cultures and suspensions using elastic light-scattering spectroscopy", Applied Optics, V.46, 4834-4842 (2007) PDF
Yicong Wu, Wei Zheng and Jianan Y. Qu*, "Sensing cell metabolism by time-resolved autofluorescence", Optics Letters, V.31, 3122-3124 (2006) PDF
• Yicong Wu and Jianan Y. Qu*,, "Autofluorescence spectroscopy of epithelial tissues", Journal of Biomedical Optics, V.11, 054023 (2006) PDF
• Yicong Wu and Jianan Y. Qu*, "Combined depth- and time-resolved autofluorescence spectroscopy of epithelial tissue", Optics Letters, V.31, 1833-1835 (2006) PDF
• Yicong Wu and Jianan Y. Qu*, "Two-photon autofluorescence spectroscopy and second harmonic generation of epithelial tissue", Optics Letters, V.30, 3045-3047 (2005) PDF
Tao T. Wu, Tak Hong Cheung, So Fan Yim, Yick Fu Wong and Jianan Y. Qu*, "Study of dynamic process of acetic acid induced whitening in epithelial tissues at cellular level", Optics Express, V.13, 4963-4973 (2005) PDF  MOVIE1  MOVIE2  MOVIE3
Yicong Wu, Peng Xi, Tak-Hong Cheung, Mei-Yung Yu and Jianan Y. Qu*, "Depth-resolved fluorescence spectroscopy of normal and dysplastic cervical tissue", Optics Express, V.13, 382-388 (2005) PDF  MOVIE1  MOVIE2
Yicong Wu, Peng Xi, Tak-Hong Cheung, Mei-Yung Yu and Jianan Y. Qu*, "Depth-resolved fluorescence spectroscopy reveals layered structure of tissue", Optics Express, V.12, 3218-3223 (2004) PDF
Wumei Lin, Powing Yuen, Xin Yuan, Jonathan Sham, Pengcheng Shi, William I. Wei and Jianan Y. Qu*, "Classification of in vivo autofluorescence spectra using support vector machine", Journal of Biomedical Optics, V.9, 180-186 (2004) PDF
Manhong Chan, Wumei Lin, Changhe Zhou and Jianan Y. Qu*, "A miniaturized three-dimensional endoscopic imaging system based on active stereovision", Applied Optics, V.42, 1888-1898 (2003) PDF
Tao Wu, T. H. Cheung, K. W. Lo, Mei-Yung Yu and Jianan Y. Qu*, "Preliminary study of detecting neoplastic growth in vivo with real time calibrated autofluorescence imaging", Optics Express, V.11, 291-298 (2003) PDF  MOVIE
Hanpeng Chang, Jianan Y. Qu*, Powing Yuen, Jonathan Sham, Dora Kwang and William I. Wei, "Light-induced autofluorescence spectroscopy for detection of nasopharyngeal carcinoma in vivo", Applied Spectroscopy, V.56, 1361-1367 (2002) PDF
Jianan Y. Qu, Hanpeng Chang and Shenming Xiong, "Fluorescence spectral imaging for characterization of tissue based on multivariate statistical analysis", Journal of the Optical Society of America, A, V.19, 1823-1831 (2002) PDF
Jianan Y. Qu and Lan Shao, "Multiple band-pass-filtering method for improvement on prediction accuracy of linear multivariate analysis", Applied Spectroscopy, V.55, 1414-1421 (2001) PDF
Jianan Y. Qu, Hanpeng Chang and Shenming Xiong, "Optical processing of light induced autofluorescence for characterization of tissue pathology", Optics Letters, V.26,1268-1270 (2001) PDF
Jianan Y. Qu and Jianwen Hua, "Calibrated fluorescence imaging of tissue in vivo", Applied Physics Letters, V.78,4040-4042(2001) PDF
Jianan Y. Qu and Lan Shao, "Near-IR Raman instrument for rapid and quantitative measurements of clinically important analytes", Review of Scientific Instruments, V.72 2717-2723 (2001) PDF
Jianan Y. Qu, Zhijian Huang and Jianwen Hua, "Excitation and collection geometry insensitive fluorescence imaging of tissue-simulating turbid media", Applied Optics, V. 39, 3344-3356 (2000) PDF
Jianan Y. Qu, Po Wing Yuen, Zhijian Huang, Dora Kwong, Jonathan Sham, Siu Lung Lee, Wai Kuen Ho, and William I. Wei, "Preliminary Study of in vivo Autofluorescence of Nasopharyngeal Carcinoma and Normal Tissue", Lasers in Surgery and Medicine, V. 26, 432-440 (2000) PDF
Jianan Y. Qu, Jianwen Hua and Zhijian Huang, "Correction of Geometrical Effects on Fluorescence Imaging of Tissue" Optics Communications (Full Length Paper), V. 176, 319-326 (2000) PDF
Jianan Y. Qu, Zhijian Huang, and Jianwen Hua, "Mapping the fluorescence yield on turbid media", Applied Physics Letters, V.76, 970-972 (2000) PDF

  Representative invited talks (selected from over 40 invited talks and lectures)
"Mechanism and applications of new fluorescent compounds produced by femtosecond laser surgery in biological tissue", Optical Biopsy XV: Toward Real-Time Spectroscopic Imaging and Diagnosis, BiOS, Photonics West, January 28 - February 2, 2017, San Francisco, California, USA
"Two-photon Excited Blood Autofluorescence for In Vivo Imaging and Flow Cytometry", Topical Meeting on Biomedical Optics, Optical Society of America, April 29- May 2, 2012, Miami, Florida, USA
"Two-photon excited hemoglobin fluorescence for label-free imaging of microvasculature", COLD SPRING HARBOR ASIA CONFERENCES: New Advances in Optical Imaging of Live Cells and Organisms, May 9 - 13, 2011, Suzhou, China
"Seeing is believing: label-free bioanalytical imaging and microscopy", 11th OWLS Optics Within Life Sciences: Optics-based Therapeutics, Diagnostics and Analytics, September 28-30, 2010, Quebec City, Canada
"Nonlinear optical microscopy of multi-color excitations from ultrafast supercontinuum generation: in vivo imaging of living cells and tissues", Engineering Conferences International: Advances in Optics for Biotechnology, Medicine and Surgery, June 28-July 02, 2009, Burlington, Vermont, USA
"Quantitative imaging of early cervical cancer: technology and mechanism", Conference on Biomedical Applications of Light Scattering III, BiOS' 09, Jan. 24-29, 2009, San Jose, California, USA
"Monitoring cellular metabolic pathways by wavelength- and time-resolved intracellular autofluorescence", European Conferences on Biomedical Optics, June 17-21, 2007, Munich, Germany
"Time-resolved autofluorescence and autofluorescence spectroscopy", Engineering Conferences International: Advances in Optics for Biotechnology, Medicine and Surgery, June 10-14, 2007, Naples, Florida, USA
"Fluorescence spectroscopy and imaging of biological tissues in vivo", International Symposium on Biophotonics (Biophotonics 2004), June 21-24, 2004, Stockholm, Sweden
"Advances in calibrated fluorescence imaging of pre-malignant lesions in vivo", Annual International Conference on Advanced Laser Technology (ALT' 03, Focused on Biomedical Optics), 19-23 September 2003, Silsoe, UK
"Fluorescence spectral imaging for characterization of tissue based on multivariate statistical analysis", the Second International Conference on Biomedical Spectroscopy (from the bench to the clinic), 5-8 July 2003, Kings College, London, UK
"Real time calibrated fluorescence imaging of tissue in vivo by using the combination of fluorescence and cross-polarized reflection", Topical Meeting on Biomedical Optical Spectroscopy and Diagnostics, Optical Society of America, April 7-10, 2002, Miami Beach, Florida, USA
Patents
Jianan Y. Qu, "Method and Apparatus for Fluorescence Imaging of Tissue", US Patent No.6,343,228 (2002)
Tao Wu and Jianan Y. Qu, "Apparatus and method for optical imaging for medical diagnosis", US Patent (2012)